|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:Apaf-1
gptkb:cytochrome_c
gptkb:apoptosome
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:EC_number
|
3.4.22.62
|
|
gptkbp:encodedBy
|
CASP9 gene
|
|
gptkbp:expressedIn
|
gptkb:human
gptkb:mouse
|
|
gptkbp:function
|
initiator caspase in apoptosis
cleaves and activates executioner caspases
|
|
gptkbp:gene
|
gptkb:CASP9
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
caspase 9
|
|
gptkbp:inhibitedBy
|
gptkb:Bcl-2_family_proteins
gptkb:XIAP
|
|
gptkbp:locatedIn
|
gptkb:human_chromosome_1
|
|
gptkbp:locatedOnChromosome
|
1q36.21
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:OMIM
|
602234
|
|
gptkbp:orthologIn
|
mouse Casp9
rat Casp9
|
|
gptkbp:PDB
|
1JXQ
|
|
gptkbp:relatedTo
|
intrinsic apoptosis pathway
mitochondrial pathway of apoptosis
|
|
gptkbp:structure
|
contains CARD domain
|
|
gptkbp:substrate
|
executioner caspases (e.g., caspase 3, caspase 7)
|
|
gptkbp:UniProtID
|
gptkb:P55211
|
|
gptkbp:bfsParent
|
gptkb:CASP9
gptkb:E2F_transcription_factor_1
|
|
gptkbp:bfsLayer
|
8
|