|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:caspase_8
gptkb:caspase_9
caspase 3
|
|
gptkbp:alternativeName
|
CMH-1
ICE-LAP3
Mch3
apoptotic protease Mch-3
|
|
gptkbp:catalyzes
|
gptkb:cysteine_protease
|
|
gptkbp:cleaves_after_aspartic_acid
|
yes
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:EC_number
|
3.4.22.60
|
|
gptkbp:Entrez_Gene_ID
|
840
ENSG00000165806
|
|
gptkbp:expressedIn
|
gptkb:human
gptkb:mouse
right
many tissues
|
|
gptkbp:function
|
execution-phase apoptosis
|
|
gptkbp:GO_term
|
GO:0004197 (cysteine-type endopeptidase activity)
GO:0006915 (apoptotic process)
|
|
gptkbp:HGNC_ID
|
1509
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
caspase 7
|
|
gptkbp:inhibitedBy
|
inhibitor of apoptosis proteins (IAPs)
|
|
gptkbp:locatedIn
|
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q25
|
|
gptkbp:molecularWeight
|
34 kDa (precursor)
|
|
gptkbp:OMIM
|
601761
|
|
gptkbp:orthologInMouse
|
Casp7
|
|
gptkbp:PDB
|
1F1J
1K86
1SHJ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
cleavage
|
|
gptkbp:product
|
CASP7 gene
|
|
gptkbp:RefSeq
|
NP_001219
|
|
gptkbp:relatedTo
|
caspase 3
caspase 6
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:structure
|
heterotetramer (2 large and 2 small subunits)
|
|
gptkbp:substrate
|
gptkb:ICAD
lamin
poly(ADP-ribose) polymerase (PARP)
|
|
gptkbp:UniProtID
|
P55210
|
|
gptkbp:bfsParent
|
gptkb:E2F_transcription_factor_1
|
|
gptkbp:bfsLayer
|
8
|