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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alias
|
gptkb:CDKN2A
gptkb:CDK4I
gptkb:INK4A
gptkb:MTS1
gptkb:cyclin-dependent_kinase_inhibitor_2A
|
|
gptkbp:alternativeSplicing
|
produces p12
produces p14ARF
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:CDKN2A_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:hasBiomarker
|
gptkb:HPV-associated_cancers
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p16INK4A
|
|
gptkbp:inhibitedBy
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:involvedIn
|
G1 phase arrest
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:9p21
|
|
gptkbp:molecularWeight
|
16 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:glioblastoma
melanoma
pancreatic cancer
bladder cancer
head and neck cancer
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn2a
|
|
gptkbp:phosphorylationStatus
|
not phosphorylated
|
|
gptkbp:regulates
|
gptkb:RB_pathway
cell cycle
|
|
gptkbp:structure
|
contains ankyrin repeats
|
|
gptkbp:UniProtID
|
gptkb:P42771
|
|
gptkbp:bfsParent
|
gptkb:INK4A
|
|
gptkbp:bfsLayer
|
7
|