cyclin E

URI: https://gptkb.org/entity/cyclin_E

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cell_cycle_regulator gptkb:protein
gptkbp:alternativeSplicing	yes
gptkbp:binds	gptkb:CDK2
gptkbp:degradedBy	gptkb:ubiquitin-proteasome_pathway
gptkbp:discoveredIn	1991
gptkbp:encodedBy	gptkb:CCNE1_gene gptkb:CCNE2_gene
gptkbp:function	regulates G1/S transition in cell cycle
gptkbp:inhibitedBy	gptkb:p21 gptkb:p27
gptkbp:location	gptkb:nucleus
gptkbp:overexpressedIn	gptkb:cancer
gptkbp:phosphorylates	gptkb:CDK2
gptkbp:regulates	gptkb:E2F_transcription_factors DNA replication
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:UniProtID	gptkb:O96020_(CCNE2) gptkb:P24864_(CCNE1)
gptkbp:bfsParent	gptkb:CDKN1A gptkb:CDKN1B gptkb:p21
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	cyclin E