|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:biologicalProcess
|
DNA-directed DNA polymerase activity
DNA primase activity
|
|
gptkbp:component
|
eukaryotic replisome
|
|
gptkbp:discoveredBy
|
gptkb:Arthur_Kornberg
|
|
gptkbp:EC_number
|
2.7.7.7
|
|
gptkbp:first_step_in
|
DNA synthesis
|
|
gptkbp:formsComplexWith
|
gptkb:primase
|
|
gptkbp:function
|
DNA replication
primase activity
synthesizes RNA-DNA primers
|
|
gptkbp:gene
|
POLA1
POLA2
PRIM1
PRIM2
|
|
gptkbp:GO_term
|
DNA replication initiation
GO:0003896
GO:0003887
|
|
gptkbp:has_catalytic_subunit
|
POLA1
|
|
gptkbp:has_large_primase_subunit
|
PRIM2
|
|
gptkbp:has_regulatory_subunit
|
POLA2
|
|
gptkbp:has_small_primase_subunit
|
PRIM1
|
|
gptkbp:hasNo
|
proofreading activity
3' to 5' exonuclease activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA polymerase alpha
|
|
gptkbp:inhibitedBy
|
aphidicolin
|
|
gptkbp:launched
|
Okazaki fragment synthesis
leading strand synthesis
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:organism
|
eukaryotes
|
|
gptkbp:otherName
|
DNA polymerase alpha-primase complex
Pol α
|
|
gptkbp:PDB
|
5EXR
|
|
gptkbp:replacedBy
|
gptkb:DNA_polymerase_delta
DNA polymerase epsilon
|
|
gptkbp:requires
|
cell division
lagging strand synthesis
Okazaki fragment synthesis
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
|
|
gptkbp:subunit
|
POLA1
POLA2
PRIM1
PRIM2
|
|
gptkbp:UniProtID
|
P09884
|
|
gptkbp:bfsParent
|
gptkb:E2F_transcription_factor_1
gptkb:DNA_polymerase_alpha-primase_complex_(eukaryotes)
|
|
gptkbp:bfsLayer
|
8
|