|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:E2F-1
gptkb:E2F_transcription_factor_1
|
|
gptkbp:disruption_phenotype
|
reduced apoptosis
increased tumor susceptibility
defective cell cycle progression
|
|
gptkbp:domain
|
DNA-binding domain
dimerization domain
transactivation domain
E2F-TDP domain
|
|
gptkbp:encodedBy
|
E2f1 gene
|
|
gptkbp:Entrez_Gene_ID
|
13555
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell cycle
transcription factor
|
|
gptkbp:gene
|
gptkb:E2f1
|
|
gptkbp:GO_term
|
GO:0008285 (negative regulation of cell proliferation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse E2f1
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_A
gptkb:DP1
gptkb:Rb1
gptkb:p53
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
human E2F1
rat E2f1
|
|
gptkbp:pathway
|
cell cycle
DNA damage response
p53 signaling pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:E2F_family
|
|
gptkbp:RefSeq
|
NP_034237.2
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
DNA replication
S-phase entry
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:transcriptional_activator
|
yes
|
|
gptkbp:transcriptional_repressor
|
yes
|
|
gptkbp:UniProtID
|
Q61586
|
|
gptkbp:bfsParent
|
gptkb:E2F_transcription_factor_1
|
|
gptkbp:bfsLayer
|
8
|