|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:RB_protein
gptkb:pRb
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
gptkb:Brenda_Gallie
|
|
gptkbp:encodedBy
|
gptkb:RB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:RB1
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
tumor suppressor
regulation of cell cycle
|
|
gptkbp:HGNC_ID
|
9884
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
retinoblastoma protein
|
|
gptkbp:inhibitedBy
|
gptkb:E2F_transcription_factors
cell proliferation
|
|
gptkbp:interactsWith
|
gptkb:BRG1
gptkb:p16INK4a
gptkb:MDM2
gptkb:Cyclin_D1
gptkb:E2F1
gptkb:HDAC1
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q14
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
|
|
gptkbp:OMIM
|
614041
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:2YUE
1AD6
2QDJ
|
|
gptkbp:phosphorylates
|
gptkb:cyclin-dependent_kinases
releases E2F
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
G1/S cell cycle transition
|
|
gptkbp:role
|
apoptosis
differentiation
cellular senescence
DNA damage response
|
|
gptkbp:structure
|
contains C-terminal domain
contains N-terminal domain
contains pocket domain
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:unphosphorylatedForm
|
binds E2F
|
|
gptkbp:bfsParent
|
gptkb:RB1
|
|
gptkbp:bfsLayer
|
6
|