transcription factor E2F1

URI: https://gptkb.org/entity/transcription_factor_E2F1
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alternativeName gptkb:E2F-1
gptkb:E2F_transcription_factor_1
gptkbp:associatedWith gptkb:cancer
apoptosis
cell proliferation
gptkbp:domain DNA-binding domain
dimerization domain
transactivation domain
gptkbp:encodedBy gptkb:E2F1_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000101412
1869
gptkbp:family gptkb:E2F_family
gptkbp:function regulation of cell cycle
apoptosis induction
regulation of DNA replication
gptkbp:gene gptkb:E2F1
gptkbp:HGNC_ID gptkb:HGNC:3113
https://www.w3.org/2000/01/rdf-schema#label transcription factor E2F1
gptkbp:interactsWith gptkb:Cyclin_A
gptkb:CDK2
gptkb:DP1
retinoblastoma protein (pRB)
gptkbp:length 437 amino acids
gptkbp:locatedOnChromosome gptkb:20q11.2
gptkbp:molecularWeight 47 kDa
gptkbp:OMIM 189971
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 1CF7
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:regulates p73 expression
Bim expression
CDC6 expression
DHFR expression
DNA polymerase alpha expression
MCM proteins expression
PCNA expression
S-phase entry
c-Myc expression
cyclin E expression
p14ARF expression
p21 expression
p27 expression
thymidine kinase expression
transcription of cell cycle genes
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID gptkb:Q01094
gptkbp:bfsParent gptkb:E2F_transcription_factor_1
gptkbp:bfsLayer 8