|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:composedOf
|
gptkb:E2F2
gptkb:E2F3
gptkb:E2F4
gptkb:E2F5
gptkb:E2F6
gptkb:E2F7
gptkb:E2F8
gptkb:E2F1
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:expressedIn
|
eukaryotes
|
|
gptkbp:function
|
gptkb:transcription_factor
|
|
gptkbp:hasMember
|
gptkb:E2F2
gptkb:E2F3
gptkb:E2F4
gptkb:E2F5
gptkb:E2F6
gptkb:E2F7
gptkb:E2F8
gptkb:E2F1
|
|
gptkbp:interactsWith
|
gptkb:retinoblastoma_protein
|
|
gptkbp:involvedIn
|
cancer progression
tumorigenesis
|
|
gptkbp:proteinFamily
|
gptkb:E2F
|
|
gptkbp:regulates
|
gptkb:pRB_family_proteins
gptkb:cyclin-dependent_kinases
apoptosis
cell proliferation
feedback loops
growth factors
phosphorylation
transcriptional activation
cell cycle
hormones
protein-protein interactions
DNA damage response
methylation
ubiquitination
acetylation
DNA synthesis
cellular stress
transcriptional repression
chromatin remodeling
microRNAs
nutrient availability
tumor suppressors
oncogenic signals
|
|
gptkbp:relatedTo
|
DP family
|
|
gptkbp:bfsParent
|
gptkb:E2F1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E2F family
|