|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
DNA topoisomerase II alpha
TOP2A protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
DNA repair
mitosis
cell cycle
ATP binding
DNA binding
DNA topoisomerase activity
|
|
gptkbp:Entrez_Gene_ID
|
7153
|
|
gptkbp:enzymeCommissionNumber
|
5.99.1.3
|
|
gptkbp:expressedIn
|
proliferating cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
DNA replication
chromosome segregation
DNA topological change
|
|
gptkbp:gene
|
TOP2A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
topoisomerase II alpha
|
|
gptkbp:inhibitedBy
|
ICRF-193
|
|
gptkbp:interactsWith
|
gptkb:TOPBP1
gptkb:BRCA1
gptkb:p53
gptkb:Ki-67
|
|
gptkbp:length
|
1531
|
|
gptkbp:locatedOnChromosome
|
17q21-q22
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
174 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:secondary_leukemia
drug resistance
|
|
gptkbp:orthologInMouse
|
Top2a
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
|
|
gptkbp:PDB
|
1ZXM
|
|
gptkbp:phosphorylates
|
Serine 1106
Threonine 1342
|
|
gptkbp:regulates
|
gptkb:E2F_transcription_factors
cell cycle
|
|
gptkbp:requires
|
cell proliferation
chromosome condensation
sister chromatid separation
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:targetOfDrug
|
gptkb:doxorubicin
antineoplastic agent
teniposide
|
|
gptkbp:UniProtID
|
P11388
|
|
gptkbp:bfsParent
|
gptkb:Type_II_topoisomerase
gptkb:topoisomerase_II
|
|
gptkbp:bfsLayer
|
6
|