|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CYP2D6
gptkb:cytochrome_P450_2D6
gptkb:debrisoquine_4-hydroxylase
|
|
gptkbp:associatedWith
|
pharmacogenomics
adverse drug reactions
poor metabolizer phenotype
ultrarapid metabolizer phenotype
intermediate metabolizer phenotype
normal metabolizer phenotype
|
|
gptkbp:encodes
|
CYP2D6 enzyme
|
|
gptkbp:Entrez_Gene_ID
|
1565
|
|
gptkbp:enzymeClassification
|
gptkb:cytochrome_P450
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:small_intestine
brain
liver
|
|
gptkbp:fullName
|
gptkb:cytochrome_P450_family_2_subfamily_D_member_6
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
|
|
gptkbp:hasPolymorphism
|
true
|
|
gptkbp:HGNC_ID
|
HGNC:2625
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2D6 gene
|
|
gptkbp:inhibitedBy
|
gptkb:methadone
gptkb:mirabegron
gptkb:paroxetine
gptkb:propafenone
gptkb:cobicistat
gptkb:ritonavir
gptkb:sertraline
gptkb:bupropion
gptkb:duloxetine
gptkb:fluoxetine
gptkb:haloperidol
gptkb:celecoxib
gptkb:terbinafine
gptkb:ticlopidine
cimetidine
quinidine
amiodarone
drugs with CYP2D6 inhibition properties
perhexiline
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q13.2
chromosome 22
|
|
gptkbp:metabolism
|
gptkb:oxycodone
gptkb:donepezil
gptkb:ondansetron
gptkb:paroxetine
gptkb:tricyclic_antidepressants
gptkb:propafenone
gptkb:dextromethorphan
gptkb:codeine
gptkb:SSRIs
gptkb:chlorpromazine
gptkb:zuclopenthixol
gptkb:venlafaxine
gptkb:desipramine
gptkb:tamoxifen
gptkb:amitriptyline
gptkb:aripiprazole
gptkb:imipramine
gptkb:metoprolol
gptkb:duloxetine
gptkb:fluoxetine
gptkb:haloperidol
gptkb:risperidone
gptkb:yohimbine
gptkb:atomoxetine
gptkb:tramadol
gptkb:clomipramine
gptkb:nortriptyline
gptkb:terbinafine
gptkb:thioridazine
beta blockers
opioids
antipsychotics
hydrocodone
mirtazapine
perphenazine
mexiletine
tolterodine
pergolide
antiarrhythmics
bufuralol
perhexiline
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologInCat
|
gptkb:CYP2D6
|
|
gptkbp:orthologInChicken
|
CYP2D49
|
|
gptkbp:orthologInChimpanzee
|
gptkb:CYP2D6
|
|
gptkbp:orthologInCow
|
gptkb:CYP2D6
|
|
gptkbp:orthologInDog
|
CYP2D15
|
|
gptkbp:orthologInHorse
|
CYP2D50
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2d1
gptkb:Cyp2d22
|
|
gptkbp:orthologInPig
|
CYP2D25
|
|
gptkbp:orthologInZebrafish
|
cyp2d6
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:CYP2D6_protein
gptkb:cytochrome_P450_2D6
gptkb:cytochrome_P450_family_2_subfamily_D_member_6
|
|
gptkbp:bfsLayer
|
6
|