|
gptkbp:instanceOf
|
enzyme superfamily
|
|
gptkbp:abbreviation
|
CYP
|
|
gptkbp:cofactor
|
iron
|
|
gptkbp:color
|
absorbs at 450 nm
|
|
gptkbp:contains
|
gptkb:heme_cofactor
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Klingenberg
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:EC_number
|
1.14.-.-
|
|
gptkbp:function
|
synthesis of cholesterol
monooxygenase activity
drug metabolism
synthesis of steroids
synthesis of lipids
|
|
gptkbp:geneExample
|
gptkb:CYP1A2
gptkb:CYP2C9
gptkb:CYP2C19
gptkb:CYP11A1
gptkb:CYP17A1
gptkb:CYP19A1
gptkb:CYP21A2
gptkb:CYP2D6
gptkb:CYP3A4
gptkb:CYP7A1
gptkb:CYP2B6
CYP27A1
CYP2E1
CYP46A1
CYP4A11
CYP51A1
|
|
gptkbp:hasWikipediaPage
|
https://en.wikipedia.org/wiki/Cytochrome_P450
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cytochrome P450
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:milk
azole antifungals
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
mitochondria
|
|
gptkbp:MeSH_ID
|
D003562
|
|
gptkbp:OMIM
|
606635
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
fungi
plants
archaea
|
|
gptkbp:proteinFamily
|
gptkb:CYP1
gptkb:CYP2
gptkb:CYP3
gptkb:CYP4
|
|
gptkbp:relatedTo
|
NADPH
electron transport chain
CYP450 oxidoreductase
cytochrome b5
|
|
gptkbp:significance
|
pharmacogenomics
adverse drug reactions
drug-drug interactions
|
|
gptkbp:structure
|
contains heme-thiolate
|
|
gptkbp:substrate
|
xenobiotics
endogenous compounds
|
|
gptkbp:UniProtID
|
P00183
|
|
gptkbp:bfsParent
|
gptkb:CYP7_family
|
|
gptkbp:bfsLayer
|
5
|