|
gptkbp:instance_of
|
gptkb:blockade
|
|
gptkbp:approves
|
gptkb:FDA
|
|
gptkbp:atccode
|
C07 AB02
|
|
gptkbp:bioavailability
|
approximately 50%
|
|
gptkbp:brand
|
gptkb:Lopressor
gptkb:Toprol-XL
|
|
gptkbp:casnumber
|
37350-58-0
|
|
gptkbp:category
|
gptkb:C
|
|
gptkbp:chemical_formula
|
C15 H25 NO3
|
|
gptkbp:contraindication
|
gptkb:asthma
sick sinus syndrome
severe bradycardia
hypersensitivity to metoprolol
|
|
gptkbp:dosage_form
|
25 mg to 100 mg daily
|
|
gptkbp:effective_date
|
gptkb:1978
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:formulation
|
oral tablet
intravenous injection
extended-release tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
metoprolol
|
|
gptkbp:interacts_with
|
gptkb:diabetes
gptkb:digoxin
NSAIDs
antidepressants
other antihypertensives
|
|
gptkbp:lifespan
|
3 to 7 hours
|
|
gptkbp:mechanism_of_action
|
beta-adrenergic receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:side_effect
|
gptkb:depression
dizziness
fatigue
hypotension
bradycardia
|
|
gptkbp:trade
|
gptkb:Betaloc
gptkb:Metoprolol_Succinate
gptkb:Seloken
|
|
gptkbp:used_for
|
hypertension
heart failure
arrhythmias
angina pectoris
|
|
gptkbp:bfsParent
|
gptkb:CYP2_D6
|
|
gptkbp:bfsLayer
|
4
|