|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:rifampicin
|
|
gptkbp:alias
|
gptkb:cytochrome_P450_2D6
gptkb:debrisoquine_4-hydroxylase
|
|
gptkbp:associatedWith
|
treatment failure
adverse drug reactions
drug toxicity
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodedBy
|
gptkb:CYP2D6_gene
|
|
gptkbp:Entrez_Gene_ID
|
1565
|
|
gptkbp:enzymeClassification
|
gptkb:EC_1.14.14.1
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
|
|
gptkbp:hasPolymorphism
|
highly polymorphic
|
|
gptkbp:HGNC_ID
|
2593
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2D6 protein
|
|
gptkbp:inhibitedBy
|
gptkb:paroxetine
gptkb:fluoxetine
quinidine
|
|
gptkbp:length
|
497 amino acids
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q13.2
|
|
gptkbp:memberOf
|
gptkb:protein
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:mutationAssociatedWith
|
poor metabolizer phenotype
ultrarapid metabolizer phenotype
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologIn
|
gptkb:mouse_Cyp2d22
|
|
gptkbp:pathway
|
drug metabolism - cytochrome P450
metabolism of xenobiotics by cytochrome P450
|
|
gptkbp:PDB
|
2F9Q
|
|
gptkbp:RefSeq
|
gptkb:NP_000097.2
|
|
gptkbp:significance
|
pharmacogenomics
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains heme-binding domain
|
|
gptkbp:substrate
|
gptkb:tricyclic_antidepressants
gptkb:codeine
gptkb:SSRIs
gptkb:tamoxifen
beta blockers
|
|
gptkbp:tissue_specificity
|
gptkb:small_intestine
brain
liver
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:CYP2D6
|
|
gptkbp:bfsLayer
|
5
|