nortriptyline

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf antidepressant
gptkbp:approvalYear 1964
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode N06AA10
gptkbp:brand gptkb:Aventyl
gptkb:Pamelor
gptkbp:CASNumber 72-69-5
gptkbp:category analgesic
antidepressant
norepinephrine reuptake inhibitor
secondary amine
gptkbp:chemicalFormula C19H21N
gptkbp:contraindication recent myocardial infarction
concurrent MAOI use
gptkbp:discoveredBy gptkb:Geigy
gptkbp:eliminationHalfLife 18–44 hours
gptkbp:excretion urine
https://www.w3.org/2000/01/rdf-schema#label nortriptyline
gptkbp:IUPACName 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropan-1-amine
gptkbp:KEGGID D08206
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction norepinephrine reuptake inhibitor
serotonin reuptake inhibitor (weak)
gptkbp:meltingPoint 97–98°C
gptkbp:metabolism liver
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 93%
gptkbp:PubChem_CID 4543
4387
DB00540
CHEMBL1408
gptkbp:relatedTo gptkb:desipramine
gptkb:amitriptyline
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:orthostatic_hypotension
constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
gptkbp:synonym Nortrilen
gptkbp:UNII BL03SY4LXB
gptkbp:usedFor gptkb:major_depressive_disorder
peripheral neuropathy
chronic pain
migraine prophylaxis
gptkbp:bfsParent gptkb:tricyclic_antidepressants
gptkbp:bfsLayer 6