|
gptkbp:instanceOf
|
gptkb:drug
opioid
|
|
gptkbp:antidote
|
gptkb:naloxone
|
|
gptkbp:approvedBy
|
1977
|
|
gptkbp:approvedInUS
|
1995
|
|
gptkbp:ATCCode
|
N02AX02
|
|
gptkbp:bioavailability
|
70% (oral)
|
|
gptkbp:brand
|
gptkb:Conzip
gptkb:Rybix_ODT
gptkb:Ultram
gptkb:Ryzolt
|
|
gptkbp:CASNumber
|
27203-92-5
|
|
gptkbp:chemicalFormula
|
C16H25NO2
|
|
gptkbp:contraindication
|
gptkb:monoamine_oxidase_inhibitors
children under 12
severe respiratory depression
acute intoxication with alcohol
|
|
gptkbp:controlledSubstanceSchedule
|
Schedule IV (US)
|
|
gptkbp:developedBy
|
gptkb:Grünenthal_GmbH
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:eliminationHalfLife
|
6.3 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tramadol
|
|
gptkbp:interactsWith
|
gptkb:tricyclic_antidepressants
gptkb:SSRIs
MAOIs
other opioids
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
mu-opioid receptor agonist
|
|
gptkbp:metabolism
|
gptkb:O-desmethyltramadol
liver
|
|
gptkbp:molecularWeight
|
263.38 g/mol
|
|
gptkbp:overdoseSymptoms
|
coma
seizures
respiratory depression
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
20%
|
|
gptkbp:riskFactor
|
gptkb:serotonin_syndrome
seizures
dependence
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
rectal
|
|
gptkbp:sideEffect
|
nausea
constipation
dizziness
headache
drowsiness
|
|
gptkbp:usedFor
|
pain management
|
|
gptkbp:bfsParent
|
gptkb:serotonin_syndrome
|
|
gptkbp:bfsLayer
|
6
|