|
gptkbp:instanceOf
|
gptkb:drug
opioid
|
|
gptkbp:ATCCode
|
N02AA59
R05DA04
|
|
gptkbp:boilingPoint
|
250°C (decomposes)
|
|
gptkbp:brand
|
gptkb:Codral
gptkb:Nurofen_Plus
gptkb:Panadeine
gptkb:Tylenol_with_Codeine
|
|
gptkbp:CASNumber
|
76-57-3
|
|
gptkbp:chemicalFormula
|
C18H21NO3
|
|
gptkbp:contraindication
|
respiratory depression
breastfeeding
children under 12
|
|
gptkbp:derivedFrom
|
opium
|
|
gptkbp:discoveredBy
|
gptkb:Pierre_Jean_Robiquet
|
|
gptkbp:discoveredIn
|
1832
|
|
gptkbp:drugClass
|
antitussive
opioid
|
|
gptkbp:eliminationHalfLife
|
2.5–4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:foundIn
|
gptkb:Papaver_somniferum
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
codeine
|
|
gptkbp:interactsWith
|
gptkb:beer
CYP2D6 inhibitors
other CNS depressants
|
|
gptkbp:IUPACName
|
(5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
|
|
gptkbp:legalStatus
|
controlled substance (varies by country)
prescription only (most countries)
|
|
gptkbp:meltingPoint
|
154°C
|
|
gptkbp:metabolism
|
gptkb:morphine
gptkb:codeine-6-glucuronide
gptkb:norcodeine
liver
|
|
gptkbp:pregnancyCategory
|
AU: A
US: C
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL267
gptkb:DB00318
5284360
|
|
gptkbp:riskOfAddiction
|
yes
|
|
gptkbp:riskOfDependence
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
subcutaneous
rectal
|
|
gptkbp:sideEffect
|
nausea
vomiting
constipation
itching
drowsiness
respiratory depression
|
|
gptkbp:UNII
|
U62E3ZL0D8
|
|
gptkbp:usedFor
|
pain relief
cough suppression
diarrhea treatment
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:CYP2D6
|
|
gptkbp:bfsLayer
|
5
|