|
gptkbp:instanceOf
|
gptkb:drug
antidepressant
|
|
gptkbp:approvalYear
|
1987
|
|
gptkbp:approvedBy
|
gptkb:fluoxetine
|
|
gptkbp:category
|
gptkb:drug
psychotropic medication
serotonergic drug
|
|
gptkbp:contraindication
|
concurrent use with MAOIs
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:drugInteraction
|
gptkb:warfarin
gptkb:NSAIDs
gptkb:triptans
other serotonergic drugs
MAOIs
|
|
gptkbp:effect
|
increase serotonin levels in the brain
|
|
gptkbp:eliminationHalfLife
|
varies by drug
|
|
gptkbp:example
|
gptkb:citalopram
gptkb:escitalopram
gptkb:fluvoxamine
gptkb:paroxetine
gptkb:sertraline
gptkb:fluoxetine
|
|
gptkbp:fullName
|
gptkb:selective_serotonin_reuptake_inhibitors
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SSRIs
|
|
gptkbp:mechanismOfAction
|
inhibit reuptake of serotonin
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notEffectiveAgainst
|
psychotic disorders
bipolar depression (as monotherapy)
|
|
gptkbp:pregnancyCategory
|
varies by drug
|
|
gptkbp:regulates
|
prescription only
|
|
gptkbp:riskFactor
|
gptkb:discontinuation_syndrome
bleeding
weight gain
hyponatremia
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:serotonin_syndrome
nausea
headache
insomnia
dry mouth
sexual dysfunction
increased risk of suicidal thoughts in young people
|
|
gptkbp:usedFor
|
gptkb:obsessive-compulsive_disorder
gptkb:panic_disorder
gptkb:post-traumatic_stress_disorder
gptkb:major_depressive_disorder
gptkb:bulimia_nervosa
anxiety disorders
|
|
gptkbp:bfsParent
|
gptkb:CYP2D6
|
|
gptkbp:bfsLayer
|
5
|