tricyclic antidepressants

URI: https://gptkb.org/entity/tricyclic_antidepressants

GPTKB entity

Predicate	Object
gptkbp:instanceOf	class of medications
gptkbp:abbreviation	gptkb:TCA
gptkbp:administeredBy	oral route
gptkbp:contraindication	severe liver disease recent myocardial infarction
gptkbp:discoveredIn	1950s
gptkbp:drugClass	analgesic benzodiazepine antidepressant
gptkbp:eliminationHalfLife	varies by drug
gptkbp:example	gptkb:doxepin gptkb:desipramine gptkb:amitriptyline gptkb:imipramine gptkb:clomipramine gptkb:nortriptyline gptkb:trimipramine
https://www.w3.org/2000/01/rdf-schema#label	tricyclic antidepressants
gptkbp:interactsWith	gptkb:beer gptkb:monoamine_oxidase_inhibitors anticholinergic drugs antihypertensive drugs
gptkbp:legalStatus	prescription only
gptkbp:marketedAs	1957
gptkbp:mechanismOfAction	inhibit reuptake of norepinephrine and serotonin
gptkbp:metabolism	liver
gptkbp:notableFor	narrow therapeutic index broad side effect profile use in enuresis use in neuropathic pain
gptkbp:pregnancyCategory	varies by drug
gptkbp:replacedBy	gptkb:selective_serotonin_reuptake_inhibitors
gptkbp:riskFactor	QT prolongation overdose toxicity
gptkbp:sideEffect	gptkb:arrhythmia gptkb:orthostatic_hypotension constipation blurred vision weight gain sedation dry mouth urinary retention
gptkbp:structure	three-ring central structure
gptkbp:usedFor	gptkb:depression chronic pain anxiety disorders migraine prevention
gptkbp:bfsParent	gptkb:CYP2D6
gptkbp:bfsLayer	5