tricyclic antidepressants

URI: https://gptkb.org/entity/tricyclic_antidepressants

GPTKB entity

Statements (69)

Predicate	Object
gptkbp:instanceOf	gptkb:class_of_medications
gptkbp:abbreviation	gptkb:TCA
gptkbp:administeredBy	oral route
gptkbp:contraindication	severe liver disease recent myocardial infarction
gptkbp:discoveredIn	1950s
gptkbp:drugClass	gptkb:analgesic gptkb:antidepressant gptkb:benzodiazepine
gptkbp:eliminationHalfLife	varies by drug
gptkbp:example	gptkb:doxepin gptkb:desipramine gptkb:amitriptyline gptkb:imipramine gptkb:clomipramine gptkb:nortriptyline gptkb:trimipramine
gptkbp:interactsWith	gptkb:beer gptkb:monoamine_oxidase_inhibitors anticholinergic drugs antihypertensive drugs
gptkbp:legalStatus	prescription only
gptkbp:marketedAs	1957
gptkbp:mechanismOfAction	inhibit reuptake of norepinephrine and serotonin
gptkbp:metabolism	liver
gptkbp:notableFor	narrow therapeutic index broad side effect profile use in enuresis use in neuropathic pain
gptkbp:pregnancyCategory	varies by drug
gptkbp:replacedBy	gptkb:selective_serotonin_reuptake_inhibitors
gptkbp:riskFactor	QT prolongation overdose toxicity
gptkbp:sideEffect	gptkb:arrhythmia gptkb:orthostatic_hypotension constipation blurred vision weight gain sedation dry mouth urinary retention
gptkbp:structure	three-ring central structure
gptkbp:usedFor	gptkb:depression chronic pain anxiety disorders migraine prevention
gptkbp:bfsParent	gptkb:5-HTT gptkb:5HTT gptkb:SERT gptkb:SLC6A4 gptkb:SLC6A4_protein gptkb:Slc6a4 gptkb:serotonin_transporter_pathway gptkb:Tramadol gptkb:monoamine_oxidase_inhibitors gptkb:CYP2D6 gptkb:MAO_inhibitors gptkb:norepinephrine_transporter gptkb:serotonin_syndrome gptkb:serotonin_transporter gptkb:procarbazine gptkb:Stalevo gptkb:Fluoxetine gptkb:Moclobemide gptkb:Serotonin-norepinephrine_reuptake_inhibitors gptkb:Serotonin_syndrome gptkb:selective_serotonin_reuptake_inhibitors
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	tricyclic antidepressants