yohimbine

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
alkaloid
alpha-2 adrenergic receptor antagonist
gptkbp:ATCCode gptkb:G04BE03
gptkbp:CASNumber 146-48-5
gptkbp:category gptkb:veterinary_medicine
alkaloid
stimulant
aphrodisiac
plant alkaloid
gptkbp:chemicalFormula C21H26N2O3
gptkbp:contraindication pregnancy
hypertension
psychiatric disorders
gptkbp:discoveredIn 19th century
gptkbp:eliminationHalfLife 0.5–2 hours
gptkbp:excretion urine
gptkbp:firstIsolatedFrom gptkb:Pausinystalia_johimbe_bark
gptkbp:foundIn gptkb:Rauwolfia_serpentina
gptkb:Pausinystalia_johimbe
gptkbp:has_stereochemistry yes
https://www.w3.org/2000/01/rdf-schema#label yohimbine
gptkbp:interactsWith CNS stimulants
antihypertensives
antidepressants
gptkbp:IUPACName 17α-hydroxyyohimban-16α-carboxylic acid methyl ester
gptkbp:legalStatus prescription only (in some countries)
dietary supplement (in some countries)
gptkbp:mechanismOfAction alpha-2 adrenergic receptor antagonist
gptkbp:meltingPoint 231–233 °C
gptkbp:metabolism liver
gptkbp:molecularWeight 354.44 g/mol
gptkbp:PubChem_CID CHEMBL504
8969
DB01192
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect nausea
anxiety
hypertension
insomnia
tachycardia
gptkbp:solubility slightly soluble in water
soluble in ethanol
gptkbp:toxicity overdose can cause severe hypertension and tachycardia
gptkbp:UNII 3WX7A7D3BG
gptkbp:usedFor gptkb:veterinary_medicine
erectile dysfunction
sexual dysfunction
gptkbp:bfsParent gptkb:Apocynaceae
gptkbp:bfsLayer 6