gptkbp:instanceOf
|
gptkb:chemical_compound
alkaloid
alpha-2 adrenergic receptor antagonist
|
gptkbp:ATCCode
|
gptkb:G04BE03
|
gptkbp:CASNumber
|
146-48-5
|
gptkbp:category
|
gptkb:veterinary_medicine
alkaloid
stimulant
aphrodisiac
plant alkaloid
|
gptkbp:chemicalFormula
|
C21H26N2O3
|
gptkbp:contraindication
|
pregnancy
hypertension
psychiatric disorders
|
gptkbp:discoveredIn
|
19th century
|
gptkbp:eliminationHalfLife
|
0.5–2 hours
|
gptkbp:excretion
|
urine
|
gptkbp:firstIsolatedFrom
|
gptkb:Pausinystalia_johimbe_bark
|
gptkbp:foundIn
|
gptkb:Rauwolfia_serpentina
gptkb:Pausinystalia_johimbe
|
gptkbp:has_stereochemistry
|
yes
|
https://www.w3.org/2000/01/rdf-schema#label
|
yohimbine
|
gptkbp:interactsWith
|
CNS stimulants
antihypertensives
antidepressants
|
gptkbp:IUPACName
|
17α-hydroxyyohimban-16α-carboxylic acid methyl ester
|
gptkbp:legalStatus
|
prescription only (in some countries)
dietary supplement (in some countries)
|
gptkbp:mechanismOfAction
|
alpha-2 adrenergic receptor antagonist
|
gptkbp:meltingPoint
|
231–233 °C
|
gptkbp:metabolism
|
liver
|
gptkbp:molecularWeight
|
354.44 g/mol
|
gptkbp:PubChem_CID
|
CHEMBL504
8969
DB01192
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
gptkbp:sideEffect
|
nausea
anxiety
hypertension
insomnia
tachycardia
|
gptkbp:solubility
|
slightly soluble in water
soluble in ethanol
|
gptkbp:toxicity
|
overdose can cause severe hypertension and tachycardia
|
gptkbp:UNII
|
3WX7A7D3BG
|
gptkbp:usedFor
|
gptkb:veterinary_medicine
erectile dysfunction
sexual dysfunction
|
gptkbp:bfsParent
|
gptkb:Apocynaceae
|
gptkbp:bfsLayer
|
6
|