|
gptkbp:instanceOf
|
gptkb:drug
antidepressant
|
|
gptkbp:approvedBy
|
1966
|
|
gptkbp:ATCCode
|
gptkb:N06AA04
|
|
gptkbp:brand
|
gptkb:Anafranil
|
|
gptkbp:CASNumber
|
gptkb:303-49-1
|
|
gptkbp:contraindication
|
recent myocardial infarction
concurrent MAOI use
|
|
gptkbp:discoveredBy
|
gptkb:Geigy
|
|
gptkbp:eliminationHalfLife
|
19-37 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
gptkb:C19H23ClN2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
clomipramine
|
|
gptkbp:KEGGID
|
gptkb:D07714
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
|
|
gptkbp:MedlinePlusID
|
a682389
|
|
gptkbp:metabolism
|
desmethylclomipramine
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
97.7%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL137
gptkb:DB01242
2801
|
|
gptkbp:riskOfOverdose
|
death
coma
seizures
cardiac toxicity
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:routesOfMetabolism
|
liver
|
|
gptkbp:sideEffect
|
gptkb:arrhythmia
gptkb:orthostatic_hypotension
constipation
weight gain
sweating
seizures
drowsiness
dry mouth
sexual dysfunction
|
|
gptkbp:synonym
|
gptkb:3-chloroimipramine
chlorimipramine
|
|
gptkbp:UNII
|
N5VZ411J2Z
|
|
gptkbp:usedFor
|
gptkb:obsessive-compulsive_disorder
gptkb:panic_disorder
gptkb:major_depressive_disorder
narcolepsy
chronic pain
cataplexy
|
|
gptkbp:bfsParent
|
gptkb:tricyclic_antidepressants
|
|
gptkbp:bfsLayer
|
6
|