|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:CYP2D6
gptkb:debrisoquine_4-hydroxylase
gptkb:cytochrome_P450,_family_2,_subfamily_D,_polypeptide_6
|
|
gptkbp:associatedWith
|
adverse drug reaction
treatment failure
drug toxicity
breast cancer (via tamoxifen metabolism)
pain management (via codeine metabolism)
|
|
gptkbp:EC_number
|
1.14.14.1
|
|
gptkbp:encodedBy
|
gptkb:CYP2D6_gene
|
|
gptkbp:expressedIn
|
brain
liver
|
|
gptkbp:function
|
drug metabolism
xenobiotic metabolism
|
|
gptkbp:gene
|
gptkb:CYP2D6
|
|
gptkbp:hasAllele
|
over 100
|
|
gptkbp:hasPhenotype
|
extensive metabolizer
intermediate metabolizer
poor metabolizer
ultrarapid metabolizer
|
|
gptkbp:hasPolymorphism
|
high
|
|
gptkbp:HGNC_ID
|
2593
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cytochrome P450 2D6
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
|
|
gptkbp:inhibitedBy
|
gptkb:paroxetine
gptkb:bupropion
gptkb:fluoxetine
cimetidine
quinidine
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_22q13.2
|
|
gptkbp:member
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:metabolism
|
gptkb:tricyclic_antidepressants
gptkb:codeine
gptkb:SSRIs
gptkb:tamoxifen
beta blockers
opioids
antipsychotics
|
|
gptkbp:not_induced_by
|
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
2F9Q
|
|
gptkbp:RefSeq
|
gptkb:NM_000106
|
|
gptkbp:significance
|
pharmacogenomics
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:CYP2D6
|
|
gptkbp:bfsLayer
|
5
|