|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:cytochrome_P450_2D6
gptkb:debrisoquine_4-hydroxylase
|
|
gptkbp:associatedWith
|
adverse drug reactions
variable drug response
|
|
gptkbp:discoveredBy
|
gptkb:Ulf_S._von_Bahr
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:encodes
|
gptkb:CYP2D6_protein
|
|
gptkbp:Entrez_Gene_ID
|
1565
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:exons
|
9
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
brain
liver
|
|
gptkbp:fullName
|
gptkb:cytochrome_P450_family_2_subfamily_D_member_6
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasAllele
|
over 100 known alleles
|
|
gptkbp:hasPhenotype
|
extensive metabolizer
intermediate metabolizer
poor metabolizer
ultrarapid metabolizer
|
|
gptkbp:hasPolymorphism
|
true
|
|
gptkbp:hasPseudogene
|
gptkb:CYP2D7P
|
|
gptkbp:HGNC_ID
|
2593
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2D6
|
|
gptkbp:inducedBy
|
gptkb:dexamethasone
|
|
gptkbp:inhibitedBy
|
gptkb:paroxetine
gptkb:bupropion
gptkb:fluoxetine
quinidine
|
|
gptkbp:length
|
4.4 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q13.2
chromosome 22
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:metabolism
|
gptkb:tricyclic_antidepressants
gptkb:codeine
gptkb:SSRIs
gptkb:tamoxifen
beta blockers
opioids
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2d1
gptkb:Cyp2d22
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:relatedTo
|
gptkb:CYP2D7
gptkb:CYP2D8
|
|
gptkbp:significance
|
pharmacogenomics
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|