donepezil

GPTKB entity

Statements (57)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkb:acetylcholinesterase_inhibitor
gptkbp:approvedBy gptkb:FDA
1996
gptkbp:ATCCode gptkb:N06DA02
gptkbp:bioavailability 100%
gptkbp:brand gptkb:Aricept
gptkbp:CASNumber 120014-06-4
gptkbp:contraindication hypersensitivity to donepezil
gptkbp:developedBy gptkb:Eisai
gptkbp:eliminationHalfLife 70 hours
gptkbp:excretion gptkb:kidney
gptkbp:form gptkb:tablet
orally disintegrating tablet
gptkbp:hasMolecularFormula C24H29NO3
https://www.w3.org/2000/01/rdf-schema#label donepezil
gptkbp:improves acetylcholine levels
gptkbp:interactsWith gptkb:rifampicin
gptkb:ketoconazole
quinidine
anticholinergics
gptkbp:IUPACName gptkb:(RS)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
gptkbp:KEGGID gptkb:D07725
gptkbp:legalStatus prescription only
gptkbp:marketedAs gptkb:Pfizer
gptkbp:mechanismOfAction inhibits acetylcholinesterase
gptkbp:MeSH_ID D019695
gptkbp:metabolism liver
gptkbp:notRecommendedFor children
severe hepatic impairment
gptkbp:pregnancyCategory C (US)
gptkbp:prescribes mild to moderate Alzheimer's disease
severe Alzheimer's disease
gptkbp:proteinBinding 96%
gptkbp:PubChem_CID gptkb:CHEMBL502
gptkb:DB00843
3152
3041
gptkbp:riskFactor gastrointestinal bleeding
syncope
bradycardia
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
anorexia
fatigue
insomnia
muscle cramps
gptkbp:synonym gptkb:E2020
gptkbp:UNII N9ZZT4V5F5
gptkbp:usedFor gptkb:Alzheimer's_disease
gptkb:dementia
gptkbp:bfsParent gptkb:CYP2D6_gene
gptkb:ACHE
gptkb:acetylcholinesterase
gptkb:Aricept
gptkbp:bfsLayer 7