|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:p53_protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CDKN1A
gptkb:p21
gptkb:CIP1
gptkb:MDA-6
gptkb:SDI1
|
|
gptkbp:encodes
|
gptkb:Cyclin-dependent_kinase_inhibitor_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000124762
1026
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1784
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WAF1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:cyclin-dependent_kinases
|
|
gptkbp:interactsWith
|
gptkb:Bcl-2
gptkb:Mdm2
gptkb:Cyclin_D
gptkb:Cyclin_B1
gptkb:Cyclin_A
gptkb:Cyclin_E
gptkb:GADD45
gptkb:CDK2
gptkb:CDK4
gptkb:PCNA
gptkb:SET_protein
Cdk7
Cdk9
|
|
gptkbp:involvedIn
|
apoptosis
cellular senescence
DNA damage response
cell cycle arrest
|
|
gptkbp:length
|
164 amino acids (protein product)
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
|
|
gptkbp:OMIM
|
116899
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1a
|
|
gptkbp:orthologInZebrafish
|
cdkn1a
|
|
gptkbp:product
|
p21^Cip1/Waf1
|
|
gptkbp:regulates
|
gptkb:Sp1
gptkb:STAT
gptkb:Myc
gptkb:NF-kB
gptkb:BRCA1
gptkb:p53
gptkb:TGF-beta
gptkb:E2F
gptkb:AP-2
cell differentiation
cell proliferation
cell cycle
G1 phase of cell cycle
cellular response to stress
Smad proteins
C/EBP
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:WAF
|
|
gptkbp:bfsLayer
|
5
|