|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alias
|
gptkb:TGF-β
gptkb:TGFB
|
|
gptkbp:binds
|
TGF-beta receptors
|
|
gptkbp:category
|
growth factor
cytokine
|
|
gptkbp:database
|
GeneCards:TGFB1
HGNC:11766
UniProt:P01137
|
|
gptkbp:discoveredBy
|
gptkb:Anita_B._Roberts
gptkb:Michael_B._Sporn
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:downstreamOf
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD4
|
|
gptkbp:enemyOf
|
gptkb:follistatin
gptkb:alpha2-macroglobulin
gptkb:decorin
|
|
gptkbp:family
|
gptkb:Transforming_Growth_Factor_superfamily
|
|
gptkbp:fullName
|
gptkb:Transforming_Growth_Factor_beta
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell differentiation
regulation of cell growth
regulation of immune response
regulation of extracellular matrix production
|
|
gptkbp:gene
|
gptkb:TGFB1
gptkb:TGFB2
gptkb:TGFB3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGF-beta
|
|
gptkbp:inhibitedBy
|
cell proliferation
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
25 kDa (dimer)
|
|
gptkbp:pathway
|
gptkb:SMAD_pathway
non-SMAD pathway
|
|
gptkbp:promotion
|
extracellular matrix production
|
|
gptkbp:recipient
|
gptkb:TGF-beta_receptor_type_I
gptkb:TGF-beta_receptor_type_II
gptkb:TGF-beta_receptor_type_III
|
|
gptkbp:regulates
|
angiogenesis
inflammation
immune cell function
epithelial-mesenchymal transition
|
|
gptkbp:role
|
gptkb:cancer
wound healing
cardiovascular diseases
autoimmune diseases
embryogenesis
fibrosis
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
dimeric protein
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:WAF1_gene
gptkb:p21
|
|
gptkbp:bfsLayer
|
6
|