Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:CDK_family
gptkb:retinoblastoma_protein_(Rb) |
| gptkbp:associated_with |
cellular metabolism
cellular differentiation cellular signaling cellular growth |
| gptkbp:discovered_by |
gptkb:fungus
gptkb:1980s gptkb:Paul_Nurse |
| gptkbp:established |
cyclins
|
| gptkbp:function |
regulate cell cycle
|
| gptkbp:has_role |
cancer progression
|
| https://www.w3.org/2000/01/rdf-schema#label |
cyclin-dependent kinases
|
| gptkbp:interacts_with |
gptkb:cyclin_A
gptkb:cyclin_B gptkb:cyclin_D gptkb:cyclin_E |
| gptkbp:is_aimed_at |
CDK inhibitors
|
| gptkbp:is_effective_against |
cell cycle checkpoints
|
| gptkbp:is_essential_for |
cellular proliferation
|
| gptkbp:is_involved_in |
gptkb:embryonic_development
DNA repair apoptosis cell division cellular homeostasis cellular transport chromatin remodeling immune response protein synthesis signal transduction cellular response to stress cellular senescence tumorigenesis cellular aging neurogenesis gene expression regulation cellular signaling pathways cellular adhesion cellular communication stem cell maintenance cellular repair mechanisms metabolic regulation cellular differentiation pathways cellular migration cellular invasion cellular proliferation control cellular apoptosis regulation |
| gptkbp:is_recognized_by |
invertebrates
vertebrates human cells plant cells mouse models |
| gptkbp:metabolism |
target proteins
|
| gptkbp:regulates |
dephosphorylation
phosphorylation S phase G1 phase G2 phase M phase |
| gptkbp:subgenres |
CD K6
CD K4 CD K1 CD K2 |
| gptkbp:treatment |
gptkb:healthcare_organization
|