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gptkbp:instanceOf
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gptkb:protein
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gptkbp:abbreviation
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CDKs
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gptkbp:activatedBy
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T-loop phosphorylation
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gptkbp:associatedWith
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gptkb:CDK_inhibitors_(CKIs)
gptkb:p21
gptkb:p27
gptkb:p16
cyclins
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gptkbp:cofactor
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gptkb:ATP
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gptkbp:database
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gptkb:Gene_Ontology:_GO:0004693
UniProt: P06493 (CDK1)
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gptkbp:discoveredIn
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late 1980s
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gptkbp:enzymeClassification
|
serine/threonine kinases
|
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gptkbp:example
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gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
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gptkbp:function
|
regulation of cell cycle
phosphorylation of target proteins
|
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gptkbp:homolog_in_fission_yeast
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gptkb:Cdc2
|
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gptkbp:homolog_in_yeast
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gptkb:Cdc28
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cyclin-dependent kinases
|
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gptkbp:inhibitedBy
|
CDK inhibitors
|
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gptkbp:inhibitor_drug
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gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
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gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:organism
|
eukaryotes
|
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gptkbp:pathway
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gptkb:MAPK_signaling_pathway
cell cycle pathway
|
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gptkbp:proteinFamily
|
CDK genes
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gptkbp:regulates
|
phosphorylation
dephosphorylation
proteolysis
cyclin binding
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gptkbp:requires
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gptkb:G1/S_transition
mitosis
G2/M transition
binding to cyclins
|
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gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
|
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gptkbp:structure
|
bilobed kinase domain
|
|
gptkbp:target
|
apoptosis
differentiation
transcription
cell division
DNA replication
cell cycle checkpoints
|
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gptkbp:bfsParent
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gptkb:WAF1_gene
gptkb:HGNC:1513
gptkb:p21
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gptkbp:bfsLayer
|
6
|