Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Cyclin-dependent_kinase
|
| gptkbp:associated_with |
cellular metabolism
cellular differentiation cellular signaling cellular growth |
| gptkbp:discovered_by |
gptkb:1980s
gptkb:Paul_Nurse gptkb:yeast |
| gptkbp:function |
regulate cell cycle
|
| gptkbp:has_role |
cancer progression
|
| gptkbp:have_subtypes |
gptkb:CDK6
gptkb:CDK1 gptkb:CDK2 CDK4 |
| https://www.w3.org/2000/01/rdf-schema#label |
cyclin-dependent kinases
|
| gptkbp:inhibit |
cell cycle checkpoints
|
| gptkbp:initiated_by |
cyclins
|
| gptkbp:interacts_with |
gptkb:cyclin_A
gptkb:cyclin_B gptkb:cyclin_D gptkb:cyclin_E |
| gptkbp:involved_in |
gptkb:embryonic_development
DNA repair apoptosis cell division cellular homeostasis cellular transport chromatin remodeling immune response protein synthesis signal transduction cellular response to stress cellular senescence tumorigenesis cellular aging neurogenesis gene expression regulation cellular signaling pathways cellular adhesion cellular communication stem cell maintenance cellular repair mechanisms metabolic regulation cellular differentiation pathways cellular migration cellular invasion cellular proliferation control cellular apoptosis regulation |
| gptkbp:is_essential_for |
cellular proliferation
|
| gptkbp:is_recognized_by |
invertebrates
vertebrates human cells plant cells mouse models |
| gptkbp:is_regulated_by |
dephosphorylation
phosphorylation S phase G1 phase G2 phase M phase |
| gptkbp:is_targeted_at |
CDK inhibitors
|
| gptkbp:phosphorylate |
target proteins
|
| gptkbp:targeted_for_therapy |
gptkb:cancer_treatment
|
| gptkbp:bfsParent |
gptkb:RB1
|
| gptkbp:bfsLayer |
6
|