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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alias
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gptkb:cellular_tumor_antigen_p53
gptkb:antigen_NY-CO-13
gptkb:phosphoprotein_p53
|
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gptkbp:degradedBy
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gptkb:MDM2
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:David_Lane
|
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gptkbp:discoveredIn
|
1979
|
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gptkbp:domain
|
regulatory domain
DNA-binding domain
oligomerization domain
transactivation domain
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gptkbp:encodedBy
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gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
most human tissues
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
|
tumor suppressor
transcription factor
|
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gptkbp:GOID
|
gptkb:GO:0008285
GO:0005634
GO:0003677
GO:0006974
GO:0006355
GO:0006915
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gptkbp:halfLife
|
increases upon DNA damage
~20 minutes (unstressed)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p53 protein
|
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gptkbp:interactsWith
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gptkb:ATR
gptkb:CBP/p300
gptkb:BAX
gptkb:GADD45
gptkb:NOXA
gptkb:PUMA
gptkb:p21
gptkb:gene
gptkb:MDM2
gptkb:BRCA1
gptkb:E2F1
gptkb:14-3-3σ
ATM
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
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gptkbp:molecularWeight
|
~53 kDa
|
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gptkbp:mutationAssociatedWith
|
gptkb:cancer
deletion
insertion
missense mutation
nonsense mutation
frameshift mutation
|
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gptkbp:orthologIn
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gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
DNA repair
metabolism
angiogenesis
cell cycle
senescence
regulated by phosphorylation
regulated by acetylation
regulated by ubiquitination
activated by DNA damage
activated by oncogene activation
negatively regulated by MDM2
regulated by methylation
regulated by sumoylation
|
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gptkbp:role
|
cellular senescence
genome stability
cell cycle arrest
apoptosis induction
response to cellular stress
prevention of tumorigenesis
|
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gptkbp:significance
|
gptkb:Li-Fraumeni_syndrome
multiple cancer types
|
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gptkbp:structure
|
tetramer
|
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gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:WAF1_gene
|
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gptkbp:bfsLayer
|
6
|