|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:c-Myc
gptkb:MYC_proto-oncogene
gptkb:v-Myc
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:binds
|
E-box DNA sequences
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
gptkb:George_D._Glover
|
|
gptkbp:encodes
|
gptkb:c-Myc_protein
|
|
gptkbp:Entrez_Gene_ID
|
4609
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:firstDescribed
|
1979
|
|
gptkbp:formsComplexWith
|
gptkb:MAX_protein
|
|
gptkbp:HGNC_ID
|
7553
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Myc
|
|
gptkbp:involvedIn
|
gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
Small Cell Lung Cancer
transcription regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_8_(human)
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:orthologInMouse
|
gptkb:Myc_(mouse)
gptkb:Myc_(rat)
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:phosphorylates
|
gptkb:CDK_kinases
|
|
gptkbp:proteinFamily
|
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
metabolism
angiogenesis
cell growth
DNA replication
cell cycle
chromatin structure
stem cell maintenance
cellular metabolism
mitochondrial biogenesis
ribosome biogenesis
cellular proliferation
|
|
gptkbp:target
|
antisense oligonucleotides
small molecule inhibitors
microRNAs
|
|
gptkbp:transcriptionFactorFor
|
many genes
|
|
gptkbp:translocationIn
|
t(8;14)(q24;q32) in Burkitt lymphoma
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:Inside_Job
|
|
gptkbp:bfsLayer
|
5
|