|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
produces isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
chronic lymphocytic leukemia
follicular lymphoma
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_J._Korsmeyer
|
|
gptkbp:encodedBy
|
gptkb:BCL2_gene
|
|
gptkbp:Entrez_Gene_ID
|
596
|
|
gptkbp:expressedIn
|
gptkb:B_cells
various tissues
|
|
gptkbp:fullName
|
gptkb:B-cell_lymphoma_2
|
|
gptkbp:function
|
regulation of apoptosis
anti-apoptotic protein
|
|
gptkbp:HGNC_ID
|
990
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bcl-2
|
|
gptkbp:inhibitedBy
|
gptkb:Bax
gptkb:Bak
apoptosis
|
|
gptkbp:interactsWith
|
gptkb:Bcl-xL
gptkb:Bid
gptkb:Bim
gptkb:Mcl-1
Bad
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
nuclear envelope
mitochondrial outer membrane
|
|
gptkbp:locatedOn
|
gptkb:chromosome_18
|
|
gptkbp:memberOf
|
gptkb:Bcl-2_protein_family
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
increased cell survival
|
|
gptkbp:OMIM
|
151430
|
|
gptkbp:overexpressedIn
|
common in cancers
|
|
gptkbp:PDB
|
gptkb:1G5M
|
|
gptkbp:phosphorylationAffects
|
gptkb:software
|
|
gptkbp:regulates
|
cell death
cytochrome c release
mitochondrial membrane permeability
|
|
gptkbp:significance
|
prognostic marker in cancer
|
|
gptkbp:structure
|
contains BH domains
|
|
gptkbp:target
|
gptkb:oblimersen
gptkb:venetoclax
anticancer drugs
|
|
gptkbp:translocationAssociatedWith
|
follicular lymphoma
|
|
gptkbp:translocationPartner
|
gptkb:t(14;18)(q32;q21)
|
|
gptkbp:UniProtID
|
P10415
|
|
gptkbp:bfsParent
|
gptkb:WAF1_gene
gptkb:BAD_(Bcl-2-associated_death_promoter)
gptkb:BAD_protein
|
|
gptkbp:bfsLayer
|
6
|