|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
|
|
gptkbp:disease_involvement
|
gptkb:Li-Fraumeni_syndrome
Various cancers
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000141510
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.1
|
|
gptkbp:function
|
Acts as a tumor suppressor in many tumor types
Regulates cell cycle
Induces apoptosis
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:GO_term
|
GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
GO:0003700 (transcription factor activity)
GO:0006915 (apoptotic process)
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P20273
|
|
gptkbp:interactsWith
|
gptkb:CDKN1A
gptkb:CHEK2
gptkb:CREBBP
gptkb:EP300
gptkb:SIRT1
gptkb:SUMO1
gptkb:TP53BP1
gptkb:TP53BP2
gptkb:USP7
gptkb:RB1
gptkb:BAX
gptkb:WWP1
gptkb:YWHAB
gptkb:MDM2
gptkb:PTEN
gptkb:BRCA1
gptkb:E2F1
gptkb:GADD45A
ATM
|
|
gptkbp:InterPro
|
gptkb:IPR002117
gptkb:IPR011615
IPR010991
|
|
gptkbp:KEGGID
|
gptkb:hsa:7157
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
43,653 Da
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
p53 signaling pathway
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
7BWN
5XVK
6GGE
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Acetylation
Ubiquitination
|
|
gptkbp:protein_name
|
gptkb:Cellular_tumor_antigen_p53
|
|
gptkbp:proteinFamily
|
gptkb:PF00870
PS00034
PS50009
PS51061
|
|
gptkbp:Reactome
|
R-HSA-69541
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:structure
|
Tetramer
|
|
gptkbp:subcellularLocation
|
gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
|
|
gptkbp:UniProt_entry_name
|
gptkb:P53_HUMAN
|
|
gptkbp:UniProtID
|
gptkb:P20273
|
|
gptkbp:bfsParent
|
gptkb:CD22
|
|
gptkbp:bfsLayer
|
7
|