|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCC7
gptkb:LFS1
gptkb:TRP53
P53
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
adrenocortical carcinoma
osteosarcoma
|
|
gptkbp:biologicalProcess
|
DNA repair
cellular senescence
apoptotic process
cell cycle arrest
transcription regulation
protein binding
DNA binding
response to DNA damage
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:fullName
|
gptkb:tumor_protein_p53
|
|
gptkbp:function
|
gptkb:transcription_factor
gptkb:tumor_suppressor
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:HGNC_ID
|
HGNC:11998
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:mutationAssociatedWith
|
gain of function
loss of function
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:rat_Trp53
gptkb:mouse_Trp53
gptkb:zebrafish_tp53
|
|
gptkbp:pathway
|
apoptosis
cell cycle regulation
p53 signaling pathway
|
|
gptkbp:product
|
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:proteinFamily
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:regulates
|
gptkb:CDKN1A
gptkb:FAS
gptkb:BAX
gptkb:NOXA
gptkb:PUMA
gptkb:MDM2
gptkb:GADD45A
BBC3
|
|
gptkbp:significance
|
pathogenic
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:P04629
gptkb:P23560
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hsa:7157
|