|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:Siglec-2
|
|
gptkbp:associatedWith
|
leukemia
autoimmune diseases
B-cell acute lymphoblastic leukemia
|
|
gptkbp:biologicalProcess
|
negative regulation of immune response
B cell homeostasis
sialic acid binding
|
|
gptkbp:cellSurfaceMarker
|
gptkb:B_cells
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:cytoplasmicDomain
|
ITIM motifs
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:CD22_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000012124
933
|
|
gptkbp:expressedIn
|
gptkb:B_cells
|
|
gptkbp:extracellularDomain
|
immunoglobulin-like domains
|
|
gptkbp:fullName
|
gptkb:Cluster_of_Differentiation_22
|
|
gptkbp:function
|
inhibition of B cell activation
regulation of B cell receptor signaling
|
|
gptkbp:glycoprotein
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1692
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD22
|
|
gptkbp:interactsWith
|
gptkb:CD45
B cell receptor
sialylated glycoproteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
19q13.1
|
|
gptkbp:memberOf
|
gptkb:immunoglobulin_superfamily
gptkb:Siglec_family
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
autoimmunity
|
|
gptkbp:OMIM
|
107266
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:PDB
|
5VKJ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
antibody production
B cell tolerance
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
gptkb:epratuzumab
gptkb:inotuzumab_ozogamicin
immunotherapy
monoclonal antibodies
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
gptkb:P20273
|
|
gptkbp:bfsParent
|
gptkb:B-cell_ALL
gptkb:B_lymphocytes
gptkb:B_cells
|
|
gptkbp:bfsLayer
|
6
|