P53 HUMAN

GPTKB entity

Statements (96)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:cellular_tumor_antigen_p53
gptkb:antigen_NY-CO-13
gptkb:phosphoprotein_p53
gptkb:tumor_suppressor_p53
gptkbp:associatedWith gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
colorectal cancer
esophageal cancer
leukemia
melanoma
pancreatic cancer
prostate cancer
bladder cancer
head and neck cancer
hepatocellular carcinoma
gastric cancer
gptkbp:biologicalProcess DNA repair
apoptotic process
cell cycle arrest
transcription regulation
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
mitochondrion
gptkbp:discoveredBy gptkb:Arnold_J._Levine
gptkb:David_P._Lane
gptkb:Lloyd_J._Old
gptkbp:discoveredIn 1979
gptkbp:domain DNA-binding domain
oligomerization domain
transactivation domain
gptkbp:Entrez_Gene_ID 7157
ENSG00000141510
gptkbp:essentialGene true
gptkbp:function tumor suppressor
transcription factor
gptkbp:gene gptkb:TP53
gptkbp:goMolecularFunction DNA binding
transcription factor activity
gptkbp:hasIsoform gptkb:Δ133p53
gptkb:Δ160p53
gptkb:Δ40p53
gptkb:p53α
gptkb:p53β
gptkb:p53γ
https://www.w3.org/2000/01/rdf-schema#label P53 HUMAN
gptkbp:interactsWith gptkb:RPA
gptkb:CHEK2
gptkb:CREBBP
gptkb:EP300
gptkb:SIRT1
gptkb:BAX
gptkb:GADD45
gptkb:MDM2
gptkb:BRCA1
gptkb:TP73
gptkb:p21_(CDKN1A)
gptkb:14-3-3_sigma
gptkb:TP63
ATM
gptkbp:isHousekeepingGene false
gptkbp:isOncogene false
gptkbp:isTumorSuppressorGene true
gptkbp:length 393 amino acids
gptkbp:locatedOnChromosome 17p13.1
gptkbp:molecularWeight 43.7 kDa
gptkbp:mutationAssociatedWith gptkb:Li-Fraumeni_syndrome
various cancers
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Trp53
gptkbp:orthologInZebrafish tp53
gptkbp:PDB gptkb:2OCJ
gptkb:3KMD
gptkb:4MZR
1TUP
gptkbp:postTranslationalModification phosphorylation
methylation
sumoylation
ubiquitination
acetylation
gptkbp:RefSeq NP_000537.3
gptkbp:regulates apoptosis
DNA repair
metabolism
angiogenesis
senescence
cell cycle arrest
gptkbp:reviewedBy true
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
mitochondrion
gptkbp:targetOfDrug true
gptkbp:UniProtID P04637
gptkbp:bfsParent gptkb:P35222
gptkbp:bfsLayer 6