|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:cellular_tumor_antigen_p53
gptkb:antigen_NY-CO-13
gptkb:phosphoprotein_p53
gptkb:tumor_suppressor_p53
|
|
gptkbp:associatedWith
|
gptkb:leukemia
gptkb:cancer
gptkb:bladder_cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
gptkb:melanoma
colorectal cancer
esophageal cancer
pancreatic cancer
prostate cancer
head and neck cancer
hepatocellular carcinoma
gastric cancer
|
|
gptkbp:biologicalProcess
|
DNA repair
apoptotic process
cell cycle arrest
transcription regulation
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_J._Levine
gptkb:David_P._Lane
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:essentialGene
|
true
|
|
gptkbp:function
|
gptkb:transcription_factor
gptkb:tumor_suppressor
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:goMolecularFunction
|
DNA binding
transcription factor activity
|
|
gptkbp:hasIsoform
|
gptkb:Δ133p53
gptkb:Δ160p53
gptkb:Δ40p53
gptkb:p53α
gptkb:p53β
gptkb:p53γ
|
|
gptkbp:interactsWith
|
gptkb:RPA
gptkb:CHEK2
gptkb:CREBBP
gptkb:EP300
gptkb:SIRT1
gptkb:BAX
gptkb:GADD45
gptkb:MDM2
gptkb:BRCA1
gptkb:TP73
gptkb:p21_(CDKN1A)
gptkb:ATM
gptkb:14-3-3_sigma
gptkb:TP63
|
|
gptkbp:isHousekeepingGene
|
false
|
|
gptkbp:isOncogene
|
false
|
|
gptkbp:isTumorSuppressorGene
|
true
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Li-Fraumeni_syndrome
various cancers
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trp53
|
|
gptkbp:orthologInZebrafish
|
tp53
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
gptkb:4MZR
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:regulates
|
apoptosis
DNA repair
metabolism
angiogenesis
senescence
cell cycle arrest
|
|
gptkbp:reviewedBy
|
true
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:targetOfDrug
|
true
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:P23560
gptkb:P18146
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P53 HUMAN
|