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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:Transforming_protein_p21
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gptkbp:associatedWith
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gptkb:cancer
gptkb:bladder_cancer
gptkb:Costello_syndrome
gastric cancer
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gptkbp:biologicalProcess
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cell proliferation
signal transduction
GTP binding
GTPase activity
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gptkbp:cellularComponent
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gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
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gptkbp:Entrez_Gene_ID
|
3265
|
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gptkbp:enzymeClassification
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gptkb:EC_3.6.5.2
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gptkbp:firstDescribed
|
1982
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gptkbp:gene
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gptkb:HRAS
|
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gptkbp:geneType
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gptkb:tumor_suppressor
|
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gptkbp:interactsWith
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gptkb:MAP2K1
gptkb:MAPK1
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RASA1
gptkb:RASSF5
gptkb:RIN1
gptkb:SOS2
gptkb:RIN2
gptkb:RIN3
gptkb:MAP2K2
gptkb:RGL1
gptkb:RGL2
gptkb:RGL3
gptkb:ARAF
gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:RALGDS
gptkb:SOS1
gptkb:RASSF1
gptkb:RASSF10
gptkb:RASSF2
gptkb:RASSF3
gptkb:RASSF4
gptkb:RASSF6
gptkb:RASSF7
gptkb:RASSF8
gptkb:RASSF9
RALBP1
RALGAPA1
RALGAPA2
RALGAPB
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gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
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gptkbp:mutationAssociatedWith
|
oncogenic transformation
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
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gptkb:mouse_Hras
gptkb:rat_Hras
|
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gptkbp:pathway
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gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
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gptkbp:PDB
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gptkb:5P21
4Q21
|
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gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
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gptkbp:protein_name
|
gptkb:GTPase_HRas
|
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gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
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gptkbp:structure
|
contains GTP-binding domain
|
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gptkbp:subunit
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gptkb:monomer
|
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gptkbp:UniProtID
|
gptkb:P01112
|
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gptkbp:bfsParent
|
gptkb:Ras_p21
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P01112 (HRAS)
|