|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:Transforming_protein_p21
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
bladder cancer
gastric cancer
|
|
gptkbp:biologicalProcess
|
cell proliferation
signal transduction
GTP binding
GTPase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.6.5.2
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:gene
|
gptkb:HRAS
|
|
gptkbp:geneType
|
tumor suppressor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P01112 (HRAS)
|
|
gptkbp:interactsWith
|
gptkb:MAP2K1
gptkb:MAPK1
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RASA1
gptkb:RASSF5
gptkb:RIN1
gptkb:SOS2
gptkb:RIN2
gptkb:RIN3
gptkb:MAP2K2
gptkb:RGL1
gptkb:RGL2
gptkb:RGL3
gptkb:ARAF
gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:RALGDS
gptkb:SOS1
gptkb:RASSF1
gptkb:RASSF10
gptkb:RASSF2
gptkb:RASSF3
gptkb:RASSF4
gptkb:RASSF6
gptkb:RASSF7
gptkb:RASSF8
gptkb:RASSF9
RALBP1
RALGAPA1
RALGAPA2
RALGAPB
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:mutationAssociatedWith
|
oncogenic transformation
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Hras
gptkb:rat_Hras
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:5P21
4Q21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:protein_name
|
gptkb:GTPase_HRas
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
contains GTP-binding domain
|
|
gptkbp:subunit
|
monomer
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:RAS_gene
|
|
gptkbp:bfsLayer
|
5
|