|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:HRas_protein
gptkb:p21ras
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:biologicalProcess
|
apoptosis
cell differentiation
cell growth
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:domain
|
GTPase domain
effector domain
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Transforming protein p21
|
|
gptkbp:interactsWith
|
gptkb:NF1
gptkb:PI3K
gptkb:RalGDS
gptkb:GRB2
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:involvedIn
|
cellular transformation
signal relay
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p15.5
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61L
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
activated by GEFs
inactivated by GAPs
|
|
gptkbp:relatedTo
|
cell proliferation
oncogenesis
|
|
gptkbp:structure
|
gptkb:G-domain
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:UniProt:P01112
|
|
gptkbp:bfsLayer
|
5
|