|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alsoKnownAs
|
gptkb:Ras_protein
p21Ras
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:RAS_gene_family
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras p21
|
|
gptkbp:involvedIn
|
cell differentiation
cell survival
cell growth regulation
|
|
gptkbp:locale
|
inner surface of plasma membrane
|
|
gptkbp:memberOf
|
gptkb:Ras_subfamily
gptkb:small_GTPase_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61L
tumorigenesis
|
|
gptkbp:orthologIn
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:requires
|
embryonic development
cellular proliferation
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
contains G domain
contains switch I and II regions
|
|
gptkbp:target
|
anticancer drugs
biochemical research
|
|
gptkbp:UniProtID
|
gptkb:P01111_(NRAS)
gptkb:P01112_(HRAS)
P01116 (KRAS)
|
|
gptkbp:bfsParent
|
gptkb:p21ras
|
|
gptkbp:bfsLayer
|
7
|