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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:E3_ubiquitin-protein_ligase_NEDD4
gptkb:NEDD4A
gptkb:Neural_precursor_cell_expressed_developmentally_down-regulated_protein_4-1
|
|
gptkbp:associatedWith
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gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:domain
|
gptkb:WW_domain
gptkb:HECT_domain
C2 domain
|
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gptkbp:encodedBy
|
gptkb:NEDD4_gene
|
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gptkbp:enzymeCommissionNumber
|
EC 6.3.2.19
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gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
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gptkbp:gene
|
gptkb:NEDD4
|
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gptkbp:HGNC_ID
|
7727
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NEDD4-1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:ARRDC3
gptkb:ARRDC4
gptkb:ITCH
gptkb:NDFIP1
gptkb:NDFIP2
gptkb:SMURF1
gptkb:SMURF2
gptkb:WWP1
gptkb:WWP2
gptkb:Grb10
|
|
gptkbp:involves
|
signal transduction
protein degradation
regulation of cell growth
ubiquitination
|
|
gptkbp:locatedOnChromosome
|
15q21.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Nedd4
|
|
gptkbp:phosphorylates
|
Serine 221
Threonine 246
|
|
gptkbp:regulates
|
cell signaling pathways
membrane protein turnover
protein stability
|
|
gptkbp:substrate
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:IGF-1R
gptkb:TGF-beta_receptor
gptkb:AKT
gptkb:PTEN
gptkb:ENaC
|
|
gptkbp:UniProtID
|
Q96PU5
|
|
gptkbp:bfsParent
|
gptkb:PTEN
|
|
gptkbp:bfsLayer
|
5
|