|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
Atrophin-1-interacting protein 2
WW domain-containing protein 2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
prostate cancer
glioma
|
|
gptkbp:biologicalProcess
|
regulation of transcription
protein ubiquitination
ubiquitin-protein transferase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:domain
|
gptkb:WW_domain
gptkb:HECT_domain
|
|
gptkbp:encodes
|
WW domain-containing E3 ubiquitin-protein ligase 2
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000102901
11060
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
2000
|
|
gptkbp:function
|
E3 ubiquitin-protein ligase activity
|
|
gptkbp:gene
|
gptkb:WWP2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WWP2
|
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:ITCH
gptkb:PTEN
|
|
gptkbp:involves
|
protein ubiquitination
regulation of TGF-beta signaling
|
|
gptkbp:length
|
870 amino acids
|
|
gptkbp:locatedOnChromosome
|
16q22.1
chr16: 67,181,282-67,232,370
|
|
gptkbp:molecularWeight
|
~97 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:OMIM
|
605331
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Wwp2
|
|
gptkbp:pathway
|
gptkb:TGF-beta_signaling_pathway
gptkb:Ubiquitin-mediated_proteolysis
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
NEDD4 family
|
|
gptkbp:regulates
|
gptkb:TGF-beta_pathway
PTEN stability
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q9H0M0
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
|
|
gptkbp:bfsLayer
|
6
|