E3 ubiquitin-protein ligase NEDD4

URI: https://gptkb.org/entity/E3_ubiquitin-protein_ligase_NEDD4
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:NEDD4-1
Neural precursor cell expressed developmentally down-regulated protein 4
gptkbp:associatedWith gptkb:cancer
hypertension
gptkbp:discoveredBy 1992
gptkbp:domain gptkb:WW_domain
gptkb:HECT_domain
C2 domain
gptkbp:encodedBy gptkb:NEDD4_gene
gptkbp:enzymeCommissionNumber EC 2.3.2.27
gptkbp:expressedIn gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:testis
brain
heart
liver
pancreas
gptkbp:function protein ubiquitination
E3 ubiquitin ligase activity
gptkbp:gene gptkb:NEDD4
https://www.w3.org/2000/01/rdf-schema#label E3 ubiquitin-protein ligase NEDD4
gptkbp:interactsWith gptkb:AKT1
gptkb:SMAD2
gptkb:PTEN
gptkb:ENaC
gptkbp:locatedOnChromosome 15q21.3
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~120 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Nedd4
gptkbp:phosphorylates Serine 221
Threonine 246
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates cell growth
cell signaling
neuronal development
protein degradation
gptkbp:substrate gptkb:AKT1
gptkb:SMAD2
gptkb:PTEN
gptkb:ENaC
gptkbp:UniProtID P46934
gptkbp:bfsParent gptkb:NEDD4-1
gptkbp:bfsLayer 6