E3 ubiquitin-protein ligase NEDD4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:NEDD4-1 Neural precursor cell expressed developmentally down-regulated protein 4
gptkbp:associatedWith	gptkb:cancer hypertension
gptkbp:discoveredBy	1992
gptkbp:domain	gptkb:WW_domain gptkb:HECT_domain C2 domain
gptkbp:encodedBy	gptkb:NEDD4_gene
gptkbp:enzymeCommissionNumber	EC 2.3.2.27
gptkbp:expressedIn	gptkb:cancer gptkb:skeletal_muscle gptkb:kidney gptkb:placenta gptkb:testis brain heart liver pancreas
gptkbp:function	protein ubiquitination E3 ubiquitin ligase activity
gptkbp:gene	gptkb:NEDD4
gptkbp:interactsWith	gptkb:AKT1 gptkb:SMAD2 gptkb:PTEN gptkb:ENaC
gptkbp:locatedOnChromosome	15q21.3
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	~120 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Nedd4
gptkbp:phosphorylates	Serine 221 Threonine 246
gptkbp:postTranslationalModification	phosphorylation ubiquitination
gptkbp:regulates	cell growth cell signaling neuronal development protein degradation
gptkbp:substrate	gptkb:AKT1 gptkb:SMAD2 gptkb:PTEN gptkb:ENaC
gptkbp:UniProtID	P46934
gptkbp:bfsParent	gptkb:NEDD4-1
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	E3 ubiquitin-protein ligase NEDD4