Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:disease neurodegenerative diseases |
| gptkbp:C-terminalLobe |
contains active site
|
| gptkbp:catalyticResidue |
cysteine
|
| gptkbp:discoveredIn |
1995
|
| gptkbp:example |
gptkb:E6-AP
gptkb:ITCH gptkb:NEDD4 gptkb:SMURF1 gptkb:WWP1 gptkb:HUWE1 |
| gptkbp:foundIn |
gptkb:E3_ubiquitin_ligases
|
| gptkbp:function |
ubiquitin-protein transferase activity
catalyzes ubiquitin transfer |
| https://www.w3.org/2000/01/rdf-schema#label |
HECT domain
|
| gptkbp:InterPro |
gptkb:IPR000569
|
| gptkbp:involvedIn |
DNA repair
cell cycle regulation cell signaling protein degradation protein ubiquitination |
| gptkbp:length |
~350 amino acids
|
| gptkbp:N-terminalLobe |
binds E2 enzyme
|
| gptkbp:nameOrigin |
Homologous to E6-AP Carboxyl Terminus
|
| gptkbp:presentIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens gptkb:Drosophila_melanogaster |
| gptkbp:proteinFamily |
gptkb:PF00632
gptkb:PS50237 |
| gptkbp:SCOP |
1c4z
|
| gptkbp:structure |
bilobed
|
| gptkbp:bfsParent |
gptkb:NEDD4-1
|
| gptkbp:bfsLayer |
6
|