|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:disease
neurodegenerative diseases
|
|
gptkbp:C-terminalLobe
|
contains active site
|
|
gptkbp:catalyticResidue
|
cysteine
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:example
|
gptkb:E6-AP
gptkb:ITCH
gptkb:NEDD4
gptkb:SMURF1
gptkb:WWP1
gptkb:HUWE1
|
|
gptkbp:foundIn
|
gptkb:E3_ubiquitin_ligases
|
|
gptkbp:function
|
ubiquitin-protein transferase activity
catalyzes ubiquitin transfer
|
|
gptkbp:InterPro
|
gptkb:IPR000569
|
|
gptkbp:involvedIn
|
DNA repair
cell cycle regulation
cell signaling
protein degradation
protein ubiquitination
|
|
gptkbp:length
|
~350 amino acids
|
|
gptkbp:N-terminalLobe
|
binds E2 enzyme
|
|
gptkbp:nameOrigin
|
Homologous to E6-AP Carboxyl Terminus
|
|
gptkbp:presentIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:proteinFamily
|
gptkb:PF00632
gptkb:PS50237
|
|
gptkbp:SCOP
|
1c4z
|
|
gptkbp:structure
|
bilobed
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
gptkb:HERC2_gene
gptkb:HERC2
gptkb:UBE3A
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HECT domain
|