|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD221
|
|
gptkbp:associatedWith
|
gptkb:cancer
growth disorders
|
|
gptkbp:discoveredBy
|
biochemical studies in the 1980s
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
|
|
gptkbp:encodedBy
|
gptkb:IGF1R_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000140443
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:family
|
gptkb:tyrosine_kinase_receptor_family
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_1_receptor
|
|
gptkbp:function
|
regulates cell differentiation
regulates cell survival
regulates cell growth
mediates effects of IGF-1
|
|
gptkbp:gene
|
gptkb:IGF1R
|
|
gptkbp:HGNC_ID
|
5465
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF-1R
|
|
gptkbp:inhibitedBy
|
gptkb:linsitinib
figitumumab
ganitumab
|
|
gptkbp:ligand
|
gptkb:IGF-2
gptkb:IGF-1
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
chromosome 15q26.3
|
|
gptkbp:mutationAssociatedWith
|
can cause growth retardation
can cause insulin resistance
|
|
gptkbp:OMIM
|
147370
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:insulin_receptor
|
|
gptkbp:PDB
|
3D94
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:RefSeq
|
gptkb:NM_000875
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P08069
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
|
|
gptkbp:bfsLayer
|
6
|