|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
amiloride-sensitive sodium channel
|
|
gptkbp:associatedWith
|
gptkb:Liddle_syndrome
cystic fibrosis
pseudohypoaldosteronism type 1
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:SCNN1B_gene
gptkb:SCNN1G_gene
SCNN1A gene
SCNN1D gene
|
|
gptkbp:foundIn
|
gptkb:cancer
gptkb:kidney
colon
sweat glands
|
|
gptkbp:fullName
|
Epithelial Sodium Channel
|
|
gptkbp:function
|
sodium ion transport
|
|
gptkbp:gene
|
SCNN1A
SCNN1B
SCNN1D
SCNN1G
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ENaC
|
|
gptkbp:inhibitedBy
|
gptkb:triamterene
gptkb:amiloride
|
|
gptkbp:location
|
apical membrane of epithelial cells
|
|
gptkbp:modulatedBy
|
serine proteases
Nedd4-2 ubiquitin ligase
|
|
gptkbp:mutationAssociatedWith
|
hypertension
salt wasting
|
|
gptkbp:orthologIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:permeableTo
|
K+
Na+
|
|
gptkbp:regulates
|
gptkb:aldosterone
gptkb:vasopressin
|
|
gptkbp:requires
|
airway surface liquid regulation
sodium reabsorption in kidney collecting duct
|
|
gptkbp:role
|
fluid balance
blood pressure regulation
electrolyte homeostasis
|
|
gptkbp:structure
|
heterotrimeric
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
gamma subunit
delta subunit
|
|
gptkbp:target
|
diuretic drugs
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
|
|
gptkbp:bfsLayer
|
6
|