gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
gptkbp:alias
|
gptkb:JV15-2
gptkb:MADH3
gptkb:hSMAD3
|
gptkbp:alternativeSplicing
|
yes
|
gptkbp:chromosomeArm
|
15q22.33
|
gptkbp:discoveredBy
|
Ying E Zhang et al.
|
gptkbp:discoveredIn
|
1996
|
gptkbp:encodes
|
gptkb:Mothers_against_decapentaplegic_homolog_3
|
gptkbp:Entrez_Gene_ID
|
4088
ENSG00000166949
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
|
gptkbp:fullName
|
gptkb:SMAD_family_member_3
|
gptkbp:function
|
signal transduction
transcription factor
|
gptkbp:geneType
|
protein-coding
|
gptkbp:HGNC_ID
|
6769
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD3
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:TGFBR1
gptkb:SMAD4
|
gptkbp:length
|
425 amino acids
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
gptkbp:locatedOnChromosome
|
15
|
gptkbp:molecularWeight
|
48 kDa
|
gptkbp:mutationAssociatedWith
|
gptkb:Loeys-Dietz_syndrome
osteoarthritis
aneurysm
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
gptkbp:pathway
|
gptkb:TGF-beta_signaling_pathway
|
gptkbp:PDB
|
gptkb:1U7V
gptkb:1MK2
1OZJ
|
gptkbp:phosphorylates
|
Serine 423
Serine 425
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
immune response
extracellular matrix production
|
gptkbp:UniProtID
|
P84022
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
gptkb:SMAD4
gptkb:AXIN1
|
gptkbp:bfsLayer
|
6
|