|
gptkbp:instanceOf
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gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NEDD4
KIAA0093
hNEDD4
|
|
gptkbp:associatedWith
|
gptkb:Liddle_syndrome
|
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gptkbp:biologicalProcess
|
protein ubiquitination
ubiquitin-protein transferase activity
regulation of sodium ion transport
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:domain
|
gptkb:WW_domain
gptkb:HECT_domain
C2 domain
|
|
gptkbp:encodes
|
Neural precursor cell expressed developmentally down-regulated protein 4
|
|
gptkbp:Entrez_Gene_ID
|
4734
ENSG00000133119
|
|
gptkbp:expressedIn
|
gptkb:peripheral_blood_leukocyte
gptkb:cancer
gptkb:skeletal_muscle
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
bone marrow
colon
pancreas
fetal liver
fetal brain
fetal heart
fetal kidney
fetal lung
fetal spleen
fetal thymus
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
|
gptkbp:HGNC_ID
|
7727
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:AKT1
gptkb:SGK1
gptkb:SMAD2
gptkb:SMAD3
gptkb:ITCH
gptkb:PTEN
ENaC subunits
GRB10
|
|
gptkbp:involvedIn
|
ubiquitin-mediated proteolysis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Nedd4
|
|
gptkbp:proteinFamily
|
HECT domain E3 ligase
|
|
gptkbp:regulates
|
protein stability
ENaC (epithelial sodium channel)
|
|
gptkbp:UniProtID
|
Q96PU5
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NEDD4A
|