|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
E3 ubiquitin-protein ligase SMURF1
SMAD ubiquitination regulatory factor 1
hSMURF1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
protein degradation
regulation of cell growth
protein ubiquitination
ubiquitin-protein transferase activity
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:domain
|
gptkb:WW_domain
gptkb:HECT_domain
|
|
gptkbp:encodedBy
|
SMURF1 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000127831
|
|
gptkbp:fullName
|
SMAD specific E3 ubiquitin protein ligase 1
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
regulation of TGF-beta signaling pathway
|
|
gptkbp:gene
|
gptkb:SMURF1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:16809
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMURF1
|
|
gptkbp:inhibitedBy
|
increases TGF-beta signaling
|
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:RhoA
gptkb:SMAD1
gptkb:SMAD7
|
|
gptkbp:length
|
757 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
86 kDa
|
|
gptkbp:OMIM
|
605568
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Smurf1
|
|
gptkbp:pathway
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_022739
|
|
gptkbp:regulates
|
cell migration
neuronal development
cell polarity
osteoblast differentiation
SMAD protein stability
bone morphogenetic protein signaling
|
|
gptkbp:UniProtID
|
Q9HCE7
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
|
|
gptkbp:bfsLayer
|
6
|