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gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
E3 ubiquitin-protein ligase SMURF2
SMAD ubiquitination regulatory factor 2
|
|
gptkbp:associatedWith
|
gptkb:cancer
cellular senescence
fibrosis
|
|
gptkbp:biologicalProcess
|
ubiquitin-protein transferase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
2000s
|
|
gptkbp:encodedBy
|
SMURF2 gene
|
|
gptkbp:Entrez_Gene_ID
|
64750
ENSG00000108854
|
|
gptkbp:fullName
|
SMAD specific E3 ubiquitin protein ligase 2
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
|
gptkbp:HGNC_ID
|
HGNC:16804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMURF2
|
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMURF1
gptkb:SMAD7
RNF11
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
ubiquitin-dependent protein catabolic process
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q23.3
|
|
gptkbp:OMIM
|
606797
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell migration
cell cycle
TGF-beta receptor signaling
|
|
gptkbp:UniProtID
|
Q9HAU4
|
|
gptkbp:bfsParent
|
gptkb:NEDD4-1
|
|
gptkbp:bfsLayer
|
6
|