|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MKK4
gptkb:JNKK1
gptkb:MEK4
gptkb:PRKMK4
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
pancreatic cancer
|
|
gptkbp:discoveredBy
|
Morrison DK et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100564
6416
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_4
|
|
gptkbp:function
|
gptkb:Serine/threonine-protein_kinase
MAP kinase kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0004708
|
|
gptkbp:HGNC_ID
|
gptkb:MAP2K4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K4
|
|
gptkbp:interactsWith
|
gptkb:TAK1
gptkb:JNK1
gptkb:JNK2
gptkb:MAP3K1
gptkb:p38_MAPK
gptkb:MAP3K2
gptkb:MAP3K7
gptkb:DAXX
|
|
gptkbp:locatedOnChromosome
|
17
|
|
gptkbp:location
|
gptkb:17p12
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
loss of function associated with tumorigenesis
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_MAP2K4
gptkb:rat_MAP2K4
|
|
gptkbp:pathway
|
gptkb:JNK_signaling_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:PDB
|
gptkb:3ALN
3ALO
|
|
gptkbp:phosphorylates
|
gptkb:MAPK9
gptkb:MAPK14
gptkb:MAPK8
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
stress response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P45985
|
|
gptkbp:bfsParent
|
gptkb:17q11.2
gptkb:MAPK10
gptkb:MAPK9
gptkb:MKK4
gptkb:c-Jun_N-terminal_kinase_pathway
gptkb:MAP3K1
gptkb:MAPK/JNK_pathway
gptkb:MAPK8
gptkb:MAP_kinase_kinase_(MAP2K)
gptkb:R-HSA-5673005
gptkb:DLK
gptkb:Mitogen-activated_protein_kinase_8
|
|
gptkbp:bfsLayer
|
7
|