|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PRKMK2
MAPKKK2
MEKK2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
signal transduction
regulation of apoptosis
protein kinase activity
cellular response to stress
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000107968
10746
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Mitogen-activated protein kinase kinase kinase 2
|
|
gptkbp:function
|
gptkb:MAPK_signaling_pathway
serine/threonine protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:MAP3K2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K2
|
|
gptkbp:interactsWith
|
gptkb:MAP2K6
gptkb:MAPK9
gptkb:MAP2K4
gptkb:CDC42
gptkb:MAPK14
gptkb:MAPK8
gptkb:RAC1
gptkb:MAP2K5
|
|
gptkbp:length
|
619
|
|
gptkbp:locatedOnChromosome
|
2
|
|
gptkbp:location
|
2q14.3
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map3k2
|
|
gptkbp:pathway
|
gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:p38_MAPK_pathway
ERK5 signaling pathway
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K6
gptkb:MAP2K4
gptkb:MAP2K5
Serine/Threonine residues
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
inflammatory response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q9Y2U5
|
|
gptkbp:bfsParent
|
gptkb:MAP2K3
gptkb:MKK4
|
|
gptkbp:bfsLayer
|
7
|