Mitogen-activated protein kinase 8

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_8
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:MAP2K4
gptkb:MAP2K7
gptkbp:alsoKnownAs gptkb:JNK1
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
gptkb:diabetes
gptkbp:discoveredBy 1994
gptkbp:encodedBy gptkb:MAPK8_gene
gptkbp:Entrez_Gene_ID 5599
gptkbp:enzymeClassification gptkb:EC_2.7.11.24
gptkbp:expressedIn gptkb:skeletal_muscle
brain
heart
liver
gptkbp:function signal transduction
regulation of apoptosis
cellular stress response
gptkbp:gene gptkb:MAPK8
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase 8
gptkbp:inhibitedBy gptkb:SP600125
gptkb:JNK-IN-8
gptkbp:involves gptkb:MAPK_signaling_pathway
apoptosis pathway
gptkbp:locatedOnChromosome gptkb:chromosome_10q11.22
gptkbp:member gptkb:MAP_kinase_family
gptkb:JNK_subgroup
gptkbp:molecularWeight 46 kDa
gptkbp:OMIM 601158
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Mapk8
gptkbp:PDB 3V6S
gptkbp:phosphorylates gptkb:ATF2
gptkb:ELK1
gptkb:c-Jun
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates cell differentiation
cell proliferation
transcription factors
cell death
gptkbp:structure serine/threonine kinase domain
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:P45983
gptkbp:bfsParent gptkb:P42680
gptkbp:bfsLayer 6