Mitogen-activated protein kinase 8

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:MAP2K4 gptkb:MAP2K7
gptkbp:alsoKnownAs	gptkb:JNK1
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:Parkinson's_disease gptkb:cancer gptkb:diabetes
gptkbp:discoveredBy	1994
gptkbp:encodedBy	gptkb:MAPK8_gene
gptkbp:Entrez_Gene_ID	5599
gptkbp:enzymeClassification	gptkb:EC_2.7.11.24
gptkbp:expressedIn	gptkb:skeletal_muscle brain heart liver
gptkbp:function	gptkb:cellular_stress_response signal transduction regulation of apoptosis
gptkbp:gene	gptkb:MAPK8
gptkbp:inhibitedBy	gptkb:SP600125 gptkb:JNK-IN-8
gptkbp:involves	gptkb:MAPK_signaling_pathway apoptosis pathway
gptkbp:locatedOnChromosome	gptkb:chromosome_10q11.22
gptkbp:member	gptkb:MAP_kinase_family gptkb:JNK_subgroup
gptkbp:molecularWeight	46 kDa
gptkbp:OMIM	601158
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Mapk8
gptkbp:PDB	3V6S
gptkbp:phosphorylates	gptkb:ATF2 gptkb:ELK1 gptkb:c-Jun
gptkbp:postTranslationalModification	phosphorylation ubiquitination
gptkbp:regulates	cell differentiation cell proliferation transcription factors cell death
gptkbp:structure	serine/threonine kinase domain
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:P45983
gptkbp:bfsParent	gptkb:P42680
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Mitogen-activated protein kinase 8